Cargando…

Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis

Oxetanes have received increasing interest in medicinal chemistry as attractive polar and low molecular weight motifs. The application of oxetanes as replacements for methylene, methyl, gem-dimethyl and carbonyl groups has been demonstrated to often improve chemical properties of target molecules fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Dubois, Maryne A. J., Croft, Rosemary A., Ding, Yujie, Choi, Chulho, Owen, Dafydd R., Bull, James A., Mousseau, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672821/
https://www.ncbi.nlm.nih.gov/pubmed/35024613
http://dx.doi.org/10.1039/d1md00248a