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Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis
Oxetanes have received increasing interest in medicinal chemistry as attractive polar and low molecular weight motifs. The application of oxetanes as replacements for methylene, methyl, gem-dimethyl and carbonyl groups has been demonstrated to often improve chemical properties of target molecules fo...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
RSC
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672821/ https://www.ncbi.nlm.nih.gov/pubmed/35024613 http://dx.doi.org/10.1039/d1md00248a |