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Kynurenic acid in neurodegenerative disorders—unique neuroprotection or double‐edged sword?

AIMS: The family of kynurenine pathway (KP) metabolites includes compounds produced along two arms of the path and acting in clearly opposite ways. The equilibrium between neurotoxic kynurenines, such as 3‐hydroxykynurenine (3‐HK) or quinolinic acid (QUIN), and neuroprotective kynurenic acid (KYNA)...

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Detalles Bibliográficos
Autores principales: Ostapiuk, Aleksandra, Urbanska, Ewa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673711/
https://www.ncbi.nlm.nih.gov/pubmed/34862742
http://dx.doi.org/10.1111/cns.13768