Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss

Hearing loss affects an estimated 466 million people worldwide, with a substantial fraction due to genetic causes. Approximately 16% of genetic hearing loss is caused by pathogenic mutations in STRC, a gene that encodes the protein stereocilin. To develop gene therapy strategies for patients with ST...

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Detalles Bibliográficos
Autores principales: Shubina-Oleinik, Olga, Nist-Lund, Carl, French, Courtney, Rockowitz, Shira, Shearer, A. Eliot, Holt, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673757/
https://www.ncbi.nlm.nih.gov/pubmed/34910522
http://dx.doi.org/10.1126/sciadv.abi7629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673757/
https://www.ncbi.nlm.nih.gov/pubmed/34910522
http://dx.doi.org/10.1126/sciadv.abi7629

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