MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway

Mitochondrial DNA (mtDNA) instability activates cGAS-dependent innate immune signaling by unknown mechanisms. Here, we find that Fanconi anemia suppressor genes are acting in the mitochondria to protect mtDNA replication forks from instability. Specifically, Fanconi anemia patient cells show a loss...

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Detalles Bibliográficos
Autores principales: Luzwick, Jessica W., Dombi, Eszter, Boisvert, Rebecca A., Roy, Sunetra, Park, Soyoung, Kunnimalaiyaan, Selvi, Goffart, Steffi, Schindler, Detlev, Schlacher, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673762/
https://www.ncbi.nlm.nih.gov/pubmed/34910513
http://dx.doi.org/10.1126/sciadv.abf9441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673762/
https://www.ncbi.nlm.nih.gov/pubmed/34910513
http://dx.doi.org/10.1126/sciadv.abf9441

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