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Misexpression of genes lacking CpG islands drives degenerative changes during aging
Cellular aging is characterized by disruption of the nuclear lamina and its associated heterochromatin. How these structural changes within the nucleus contribute to age-related degeneration of the organism is unclear. Genes lacking CpG islands (CGI(−) genes) generally associate with heterochromatin...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673774/ https://www.ncbi.nlm.nih.gov/pubmed/34910517 http://dx.doi.org/10.1126/sciadv.abj9111 |