Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis

Copper serves as a co-factor for a host of metalloenzymes that contribute to malignant progression. The orally bioavailable copper chelating agent tetrathiomolybdate (TM) has been associated with a significant survival benefit in high-risk triple negative breast cancer (TNBC) patients. Despite these...

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Detalles Bibliográficos
Autores principales: Ramchandani, Divya, Berisa, Mirela, Tavarez, Diamile A., Li, Zhuoning, Miele, Matthew, Bai, Yang, Lee, Sharrell B., Ban, Yi, Dephoure, Noah, Hendrickson, Ronald C., Cloonan, Suzanne M., Gao, Dingcheng, Cross, Justin R., Vahdat, Linda T., Mittal, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674260/
https://www.ncbi.nlm.nih.gov/pubmed/34911956
http://dx.doi.org/10.1038/s41467-021-27559-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674260/
https://www.ncbi.nlm.nih.gov/pubmed/34911956
http://dx.doi.org/10.1038/s41467-021-27559-z

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