CD137 (4-1BB) costimulation of CD8(+) T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

CD137 (4-1BB; TNFSR9) is an activation-induced surface receptor that through costimulation effects provide antigen-primed T cells with augmented survival, proliferation and effector functions as well as metabolic advantages. These immunobiological mechanisms are being utilised for cancer immunothera...

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Detalles Bibliográficos
Autores principales: Otano, Itziar, Azpilikueta, Arantza, Glez-Vaz, Javier, Alvarez, Maite, Medina-Echeverz, José, Cortés-Domínguez, Ivan, Ortiz-de-Solorzano, Carlos, Ellmark, Peter, Fritzell, Sara, Hernandez-Hoyos, Gabriela, Nelson, Michelle Hase, Ochoa, María Carmen, Bolaños, Elixabet, Cuculescu, Doina, Jaúregui, Patricia, Sanchez-Gregorio, Sandra, Etxeberria, Iñaki, Rodriguez-Ruiz, María E., Sanmamed, Miguel F., Teijeira, Álvaro, Berraondo, Pedro, Melero, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674279/
https://www.ncbi.nlm.nih.gov/pubmed/34911975
http://dx.doi.org/10.1038/s41467-021-27613-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674279/
https://www.ncbi.nlm.nih.gov/pubmed/34911975
http://dx.doi.org/10.1038/s41467-021-27613-w

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