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Cadmium exposure modulates the gut-liver axis in an Alzheimer’s disease mouse model

The human Apolipoprotein E4 (ApoE4) variant is the strongest known genetic risk factor for Alzheimer’s disease (AD). Cadmium (Cd) has been shown to impair learning and memory at a greater extent in humanized ApoE4 knock-in (ApoE4-KI) mice as compared to ApoE3 (common allele)-KI mice. Here, we determ...

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Detalles Bibliográficos
Autores principales: Zhang, Angela, Matsushita, Megumi, Zhang, Liang, Wang, Hao, Shi, Xiaojian, Gu, Haiwei, Xia, Zhengui, Cui, Julia Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674298/
https://www.ncbi.nlm.nih.gov/pubmed/34912029
http://dx.doi.org/10.1038/s42003-021-02898-1