Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response

Microsatellite-instable (MSI), a predictive biomarker for immune checkpoint blockade (ICB) response, is caused by mismatch repair deficiency (MMRd) that occurs through genetic or epigenetic silencing of MMR genes. Here, we report a mechanism of MMRd and demonstrate that protein phosphatase 2A (PP2A)...

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Detalles Bibliográficos
Autores principales: Yen, Yu-Ting, Chien, May, Wu, Pei-Yi, Ho, Chi-Chang, Ho, Chun-Te, Huang, Kevin Chih-Yang, Chiang, Shu-Fen, Chao, K. S. Clifford, Chen, William Tzu-Liang, Hung, Shih-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674339/
https://www.ncbi.nlm.nih.gov/pubmed/34911954
http://dx.doi.org/10.1038/s41467-021-27620-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674339/
https://www.ncbi.nlm.nih.gov/pubmed/34911954
http://dx.doi.org/10.1038/s41467-021-27620-x

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