Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids

Three-dimensional brain organoids have emerged as a valuable model system for studies of human brain development and pathology. Here we establish a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons. Using single cell RNA seq...

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Detalles Bibliográficos
Autores principales: Fiorenzano, Alessandro, Sozzi, Edoardo, Birtele, Marcella, Kajtez, Janko, Giacomoni, Jessica, Nilsson, Fredrik, Bruzelius, Andreas, Sharma, Yogita, Zhang, Yu, Mattsson, Bengt, Emnéus, Jenny, Ottosson, Daniella Rylander, Storm, Petter, Parmar, Malin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674361/
https://www.ncbi.nlm.nih.gov/pubmed/34911939
http://dx.doi.org/10.1038/s41467-021-27464-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674361/
https://www.ncbi.nlm.nih.gov/pubmed/34911939
http://dx.doi.org/10.1038/s41467-021-27464-5

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