The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

DNA-protein crosslinks (DPCs) are a specific type of DNA lesion in which proteins are covalently attached to DNA. Unrepaired DPCs lead to genomic instability, cancer, neurodegeneration, and accelerated aging. DPC proteolysis was recently identified as a specialized pathway for DPC repair. The DNA-de...

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Detalles Bibliográficos
Autores principales: Ruggiano, Annamaria, Vaz, Bruno, Kilgas, Susan, Popović, Marta, Rodriguez-Berriguete, Gonzalo, Singh, Abhay N., Higgins, Geoff S., Kiltie, Anne E., Ramadan, Kristijan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674535/
https://www.ncbi.nlm.nih.gov/pubmed/34879279
http://dx.doi.org/10.1016/j.celrep.2021.110080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674535/
https://www.ncbi.nlm.nih.gov/pubmed/34879279
http://dx.doi.org/10.1016/j.celrep.2021.110080

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