Cargando…
The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
DNA-protein crosslinks (DPCs) are a specific type of DNA lesion in which proteins are covalently attached to DNA. Unrepaired DPCs lead to genomic instability, cancer, neurodegeneration, and accelerated aging. DPC proteolysis was recently identified as a specialized pathway for DPC repair. The DNA-de...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674535/ https://www.ncbi.nlm.nih.gov/pubmed/34879279 http://dx.doi.org/10.1016/j.celrep.2021.110080 |