Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants

Glycan-masking the vaccine antigen by mutating the undesired antigenic sites with an additional N-linked glycosylation motif can refocus B-cell responses to desired epitopes, without affecting the antigen’s overall-folded structure. This study examined the impact of glycan-masking mutants of the N-t...

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Detalles Bibliográficos
Autores principales: Lin, Wei-Shuo, Chen, I-Chen, Chen, Hui-Chen, Lee, Yi-Chien, Wu, Suh-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674692/
https://www.ncbi.nlm.nih.gov/pubmed/34925381
http://dx.doi.org/10.3389/fimmu.2021.795741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674692/
https://www.ncbi.nlm.nih.gov/pubmed/34925381
http://dx.doi.org/10.3389/fimmu.2021.795741

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