HEXA-018, a Novel Inducer of Autophagy, Rescues TDP-43 Toxicity in Neuronal Cells

The autophagy-lysosomal pathway is an essential cellular mechanism that degrades aggregated proteins and damaged cellular components to maintain cellular homeostasis. Here, we identified HEXA-018, a novel compound containing a catechol derivative structure, as a novel inducer of autophagy. HEXA-018...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Shinrye, Jo, Myungjin, Lee, Hye Eun, Jeon, Yu-Mi, Kim, Seyeon, Kwon, Younghwi, Woo, Junghwa, Han, Shin, Mun, Ji Young, Kim, Hyung-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675103/
https://www.ncbi.nlm.nih.gov/pubmed/34925009
http://dx.doi.org/10.3389/fphar.2021.747975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675103/
https://www.ncbi.nlm.nih.gov/pubmed/34925009
http://dx.doi.org/10.3389/fphar.2021.747975

Ejemplares similares