Cargando…

Targeting senescence-like fibroblasts radiosensitizes non–small cell lung cancer and reduces radiation-induced pulmonary fibrosis

Cancer cell radioresistance is the primary cause of the decreased curability of non–small cell lung cancer (NSCLC) observed in patients receiving definitive radiotherapy (RT). Following RT, a set of microenvironmental stress responses is triggered, including cell senescence. However, cell senescence...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Jingshu, Li, Yan, Wan, Chao, Sun, Yajie, Dai, Xiaomeng, Huang, Jing, Hu, Yan, Gao, Yanan, Wu, Bian, Zhang, Zhanjie, Jiang, Ke, Xu, Shuangbing, Lovell, Jonathan F., Hu, Yu, Wu, Gang, Jin, Honglin, Yang, Kunyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675198/ https://www.ncbi.nlm.nih.gov/pubmed/34877934 http://dx.doi.org/10.1172/jci.insight.146334

Ejemplares similares

Downregulation of ABI2 expression by EBV-miR-BART13-3p induces epithelial-mesenchymal transition of nasopharyngeal carcinoma cells through upregulation of c-JUN/SLUG signaling
por: Huang, Jing, et al.
Publicado: (2020)

Irradiated tumor cell–derived microparticles mediate tumor eradication via cell killing and immune reprogramming
por: Wan, Chao, et al.
Publicado: (2020)

USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer
por: Dai, Xiaomeng, et al.
Publicado: (2020)

Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel
por: Dai, Xiaomeng, et al.
Publicado: (2020)

Small Extracellular Vesicles: A Novel Avenue for Cancer Management
por: Gao, Yanan, et al.
Publicado: (2021)

Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research
por: Hu, Yan, et al.
Publicado: (2022)

Follistatin Is Induced by Ionizing Radiation and Potentially Predictive of Radiosensitivity in Radiation-Induced Fibrosis Patient Derived Fibroblasts
por: Forrester, Helen B., et al.
Publicado: (2013)

Fibroblast Senescence in Idiopathic Pulmonary Fibrosis
por: Lin, Yifan, et al.
Publicado: (2020)

Radiation-induced micronuclei in human fibroblasts in relation to clonogenic radiosensitivity.
por: O'Driscoll, M. C., et al.
Publicado: (1998)

Premature senescence of cardiac fibroblasts and atrial fibrosis in patients with atrial fibrillation
por: Xie, Jun, et al.
Publicado: (2017)

Radiated tumor cell-derived microparticles effectively kill stem-like tumor cells by increasing reactive oxygen species
por: Hu, Yan, et al.
Publicado: (2023)

Analysis of senescence in gingival tissues and gingival fibroblast cultures
por: Furukawa, Masae, et al.
Publicado: (2022)

Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis
por: Liu, Xianghe, et al.
Publicado: (2018)

Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers
por: Labay, Edwardine, et al.
Publicado: (2016)

Potential role of senescent macrophages in radiation-induced pulmonary fibrosis
por: Su, Lulu, et al.
Publicado: (2021)

Human senescent fibroblasts trigger progressive lung fibrosis in mice
por: Hernandez-Gonzalez, Fernanda, et al.
Publicado: (2023)

Cancer-Associated Fibroblasts Exposed to High-Dose Ionizing Radiation Promote M2 Polarization of Macrophages, Which Induce Radiosensitivity in Cervical Cancer
por: Sheng, Yuhan, et al.
Publicado: (2023)

Ferroptosis‐Enhanced Immunotherapy with an Injectable Dextran‐Chitosan Hydrogel for the Treatment of Malignant Ascites in Hepatocellular Carcinoma
por: Meng, Jingshu, et al.
Publicado: (2023)

Dipeptidyl peptidase 4 inhibition sensitizes radiotherapy by promoting T cell infiltration
por: Tian, Yu, et al.
Publicado: (2023)

Senescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial Infarction
por: Zhu, Fuli, et al.
Publicado: (2013)

CDP138 silencing inhibits TGF-β/Smad signaling to impair radioresistance and metastasis via GDF15 in lung cancer
por: Lu, Yanwei, et al.
Publicado: (2017)

CDK16 Phosphorylates and Degrades p53 to Promote Radioresistance and Predicts Prognosis in Lung Cancer
por: Xie, Jie, et al.
Publicado: (2018)

Comprehensive Bioinformatics Analysis of Gasdermin Family of Glioma
por: Zi, Huaduan, et al.
Publicado: (2022)

Senescent Fibroblast in Oral Submucous Fibrosis Aids in Disease Progression and Malignant Transformation
por: Karnam, Shyamala, et al.
Publicado: (2022)

Survival benefit of thoracic radiotherapy plus EGFR-TKIs in patients with non-oligometastatic advanced non-small-cell lung cancer: a single-center retrospective study
por: Zhou, Fangyuan, et al.
Publicado: (2023)

Rupatadine Protects against Pulmonary Fibrosis by Attenuating PAF-Mediated Senescence in Rodents
por: Lv, Xiao-xi, et al.
Publicado: (2013)

The role of human antigen R (HuR) in modulating proliferation, senescence and radiosensitivity of skin cells
por: Yu, Daojiang, et al.
Publicado: (2022)

Erythritol Can Inhibit the Expression of Senescence Molecules in Mouse Gingival Tissues and Human Gingival Fibroblasts
por: Yokoi, Haruna, et al.
Publicado: (2023)

Enhancement of radiosensitization by metal-based nanoparticles in cancer radiation therapy
por: Su, Xiang-Yu, et al.
Publicado: (2014)

IFI35 is involved in the regulation of the radiosensitivity of colorectal cancer cells
por: Hu, Yan, et al.
Publicado: (2021)

β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma
por: Lu, Yanwei, et al.
Publicado: (2021)

DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis
por: Habiel, David M., et al.
Publicado: (2019)

Epithelial cell senescence induces pulmonary fibrosis through Nanog-mediated fibroblast activation
por: Chen, Xiang, et al.
Publicado: (2019)

KDM4C silencing inhibits cell migration and enhances radiosensitivity by inducing CXCL2 transcription in hepatocellular carcinoma
por: Zeng, Zhen, et al.
Publicado: (2023)

In vitro and in vivo study of a nanoliposomal cisplatin as a radiosensitizer
por: Zhang, Xiaomeng, et al.
Publicado: (2011)

Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy
por: Cheng, Yanan, et al.
Publicado: (2023)

Reaction of Electrons with DNA: Radiation Damage to Radiosensitization
por: Kumar, Anil, et al.
Publicado: (2019)

MAPK11 (p38β) is a major determinant of cellular radiosensitivity by controlling ionizing radiation-associated senescence: An in vitro study
por: Fernández-Aroca, D.M., et al.
Publicado: (2023)

Impact of Premature Senescence on Radiosensitivity Measured by High Throughput Cell-Based Assays
por: Mirzayans, Razmik, et al.
Publicado: (2017)

4-Hydroxynonenal Contributes to Fibroblast Senescence in Skin Photoaging Evoked by UV-A Radiation
por: Swiader, Audrey, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bk3ckjmi5hsbs74rai9m9hn43r