mTORC1 promotes malignant large cell/anaplastic histology and is a targetable vulnerability in SHH-TP53 mutant medulloblastoma

Medulloblastoma (MB), one of the most malignant brain tumors of childhood, comprises distinct molecular subgroups, with p53 mutant sonic hedgehog–activated (SHH-activated) MB patients having a very severe outcome that is associated with unfavorable histological large cell/anaplastic (LC/A) features....

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Detalles Bibliográficos
Autores principales: Conti, Valentina, Cominelli, Manuela, Pieri, Valentina, Gallotti, Alberto L., Pagano, Ilaria, Zanella, Matteo, Mazzoleni, Stefania, Pivetta, Flavia, Patanè, Monica, Scotti, Giulia M., Piras, Ignazio S., Pollo, Bianca, Falini, Andrea, Zippo, Alessio, Castellano, Antonella, Maestro, Roberta, Poliani, Pietro L., Galli, Rossella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675203/
https://www.ncbi.nlm.nih.gov/pubmed/34673573
http://dx.doi.org/10.1172/jci.insight.153462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675203/
https://www.ncbi.nlm.nih.gov/pubmed/34673573
http://dx.doi.org/10.1172/jci.insight.153462

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