Reduction in C-Peptide Levels and Influence on Pharmacokinetics and Pharmacodynamics of Insulin Preparations: How to Conduct a High-Quality Euglycemic Clamp Study

Objective: The aim of the study was to investigate the different extent of inhibition of endogenous insulin secretion by the reduction of C-peptide levels in an euglycemic clamp study and its effects on the evaluation of pharmacokinetics, pharmacodynamics of insulin preparations, and quality of clam...

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Detalles Bibliográficos
Autores principales: Tao, Yi, Zhu, Mingxue, Pu, Junliang, Zhang, Peilin, Wan, Lei, Tang, Chengyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675232/
https://www.ncbi.nlm.nih.gov/pubmed/34925042
http://dx.doi.org/10.3389/fphar.2021.786613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675232/
https://www.ncbi.nlm.nih.gov/pubmed/34925042
http://dx.doi.org/10.3389/fphar.2021.786613

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