Cargando…

P-tau and neurodegeneration mediate the effect of β-amyloid on cognition in non-demented elders

BACKGROUND: There are many pathological changes in the brains of Alzheimer’s disease (AD) patients. For many years, the mainstream view on the pathogenesis of AD believes that β-amyloid (Aβ) usually acts independently in addition to triggering functions. However, the evidence now accumulating indica...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Ling-Zhi, Hu, Hao, Wang, Zuo-Teng, Ou, Ya-Nan, Dong, Qiang, Tan, Lan, Yu, Jin-Tai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675473/ https://www.ncbi.nlm.nih.gov/pubmed/34911582 http://dx.doi.org/10.1186/s13195-021-00943-z

Ejemplares similares

Cerebrospinal fluid α-synuclein predicts neurodegeneration and clinical progression in non-demented elders
por: Li, Jie-Qiong, et al.
Publicado: (2020)

Caspase-1 variant influencing CSF tau and FDG PET levels in non-demented elders from the ADNI cohort
por: Liu, Yi, et al.
Publicado: (2022)

Genome-wide association study of hippocampal atrophy rate in non-demented elders
por: Guo, Yu, et al.
Publicado: (2019)

Correction to: Caspase-1 variant influencing CSF tau and FDG PET levels in non-demented elders from the ADNI cohort
por: Liu, Yi, et al.
Publicado: (2022)

Mild behavioral impairment is associated with β‐amyloid but not tau or neurodegeneration in cognitively intact elderly individuals
por: Lussier, Firoza Z., et al.
Publicado: (2020)

Amyloid-β levels and cognitive trajectories in non-demented pTau181-positive subjects without amyloidopathy
por: Oberstein, Timo Jan, et al.
Publicado: (2022)

Plasma markers predict changes in amyloid, tau, atrophy and cognition in non-demented subjects
por: Pereira, Joana B, et al.
Publicado: (2021)

Genome-wide association study identifies SIAH3 locus influencing the rate of ventricular enlargement in non-demented elders
por: Li, Xian, et al.
Publicado: (2019)

Astrocytic function is associated with both amyloid-β and tau pathology in non-demented APOE ϵ4 carriers
por: Spotorno, Nicola, et al.
Publicado: (2022)

MAPT rs242557 variant is associated with hippocampus tau uptake on (18)F-AV-1451 PET in non-demented elders
por: Shen, Xue-Ning, et al.
Publicado: (2019)

Amyloid-Tau-Neurodegeneration Profiles and Longitudinal Cognition in Sporadic Young-Onset Dementia
por: Vipin, Ashwati, et al.
Publicado: (2022)

Associations between NIH Toolbox Cognition Battery and in vivo brain amyloid and tau pathology in non‐demented older adults
por: Snitz, Beth E., et al.
Publicado: (2020)

Genome-wide association study identifies CD1A associated with rate of increase in plasma neurofilament light in non-demented elders
por: Wang, Zuo-Teng, et al.
Publicado: (2019)

Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau
por: McCollum, Lauren E., et al.
Publicado: (2021)

Intensive naming training for low-educated demented and non-demented elderly
por: Ferreira, Amanda Cristina de Souza, et al.
Publicado: (2020)

Impact of SORL1 genetic variations on MRI markers in non-demented elders
por: Yin, Rui-Hua, et al.
Publicado: (2016)

APOE-ε4 modulates the association among plasma Aβ(42)/Aβ(40), vascular diseases, neurodegeneration and cognitive decline in non-demented elderly adults
por: Shi, Dai, et al.
Publicado: (2022)

Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults
por: Rodriguez-Vieitez, Elena, et al.
Publicado: (2021)

β-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population
por: Rosenberg, Anna, et al.
Publicado: (2022)

Association of cerebrospinal fluid neurogranin levels with cognition and neurodegeneration in Alzheimer’s disease
por: Xue, Mei, et al.
Publicado: (2020)

Cognitive and brain cytokine profile of non-demented individuals with cerebral amyloid-beta deposition
por: Flores-Aguilar, Lisi, et al.
Publicado: (2021)

Neurofilament light chain plasma concentration predicts neurodegeneration and clinical progression in nondemented elderly adults
por: Hu, Hao, et al.
Publicado: (2019)

Biomarkers of Inflammation Increase with Tau and Neurodegeneration but not with Amyloid-β in a Heterogenous Clinical Cohort
por: Michopoulou, Sofia, et al.
Publicado: (2022)

Fasting blood glucose and cerebrospinal fluid Alzheimer’s biomarkers in non-diabetic cognitively normal elders: the CABLE study
por: Ou, Ya-Nan, et al.
Publicado: (2020)

Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-β and tau pathology in Alzheimer’s disease
por: Wang, Zhi-Bo, et al.
Publicado: (2022)

Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia
por: Shen, Xue‐Ning, et al.
Publicado: (2020)

Genome-wide association study identifies CBFA2T3 affecting the rate of CSF Aβ(42) decline in non-demented elders
por: Dou, Kai-Xin, et al.
Publicado: (2019)

Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals
por: Biel, Davina, et al.
Publicado: (2021)

Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition
por: Arfanakis, Konstantinos, et al.
Publicado: (2013)

Association of Depression and Loneliness with Specific Cognitive Performance in Non-Demented Elderly Males
por: Tzang, Ruu-Fen, et al.
Publicado: (2015)

Rates of transition between amyloid and neurodegeneration biomarker states and to dementia among non-demented individuals: a population-based cohort study
por: Jack, Clifford R., et al.
Publicado: (2015)

The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease
por: Sato, Naoyuki, et al.
Publicado: (2015)

Brain alterations in the early Alzheimer’s continuum with amyloid-β, tau, glial and neurodegeneration CSF markers
por: Salvadó, Gemma, et al.
Publicado: (2022)

Dopaminergic and Metabolic Correlations With Cognitive Domains in Non-demented Parkinson’s Disease
por: Han, Linlin, et al.
Publicado: (2021)

Anticonvulsants in the treatment of aggression in the demented elderly: an update
por: Amann, Benedikt, et al.
Publicado: (2009)

Cohort study of electroencephalography markers of amyloid-tau-neurodegeneration pathology
por: Tanabe, Sean, et al.
Publicado: (2020)

Atrophy of the Posterior Subiculum Is Associated with Memory Impairment, Tau- and Aβ Pathology in Non-demented Individuals
por: Lindberg, Olof, et al.
Publicado: (2017)

Correlation Between Hippocampal Enlarged Perivascular Spaces and Cognition in Non-dementic Elderly Population
por: Sim, Jae Eun, et al.
Publicado: (2020)

Reference intervals for plasma amyloid-β, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment
por: Chen, Jingshan, et al.
Publicado: (2023)

CSF tau and β-amyloid as biomarkers for mild cognitive impairment
por: Hampel, Harald, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_2h740p02ifla5iadcnqomeqner