Beyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq data

We present Beyondcell, a computational methodology for identifying tumour cell subpopulations with distinct drug responses in single-cell RNA-seq data and proposing cancer-specific treatments. Our method calculates an enrichment score in a collection of drug signatures, delineating therapeutic clust...

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Detalles Bibliográficos
Autores principales: Fustero-Torre, Coral, Jiménez-Santos, María José, García-Martín, Santiago, Carretero-Puche, Carlos, García-Jimeno, Luis, Ivanchuk, Vadym, Di Domenico, Tomás, Gómez-López, Gonzalo, Al-Shahrour, Fátima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675493/
https://www.ncbi.nlm.nih.gov/pubmed/34911571
http://dx.doi.org/10.1186/s13073-021-01001-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675493/
https://www.ncbi.nlm.nih.gov/pubmed/34911571
http://dx.doi.org/10.1186/s13073-021-01001-x

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