Synthesis and Evaluation of a Fluorine-18 Radioligand for Imaging Huntingtin Aggregates by Positron Emission Tomographic Imaging

Mutations in the huntingtin gene (HTT) triggers aggregation of huntingtin protein (mHTT), which is the hallmark pathology of neurodegenerative Huntington’s disease (HD). Development of a high affinity (18)F radiotracer would enable the study of Huntington’s disease pathology using a non-invasive ima...

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Detalles Bibliográficos
Autores principales: Kaur, Tanpreet, Brooks, Allen F., Lapsys, Alex, Desmond, Timothy J., Stauff, Jenelle, Arteaga, Janna, Winton, Wade P., Scott, Peter J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675899/
https://www.ncbi.nlm.nih.gov/pubmed/34924935
http://dx.doi.org/10.3389/fnins.2021.766176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675899/
https://www.ncbi.nlm.nih.gov/pubmed/34924935
http://dx.doi.org/10.3389/fnins.2021.766176

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