Synthesis and evaluation of highly releasable and structurally stable antibody-SN-38-conjugates

Camptothecins, traditional chemotherapy drugs, have been clinically used in antibody-drug conjugates (ADCs), which refreshes the recognition that ADCs preferably incorporate highly potent payloads. However, SN-38, active metabolite of irinotecan from camptothecins, tended to be incorporated into ADC...

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Detalles Bibliográficos
Autores principales: Liu, Lianqi, Xie, Fei, Xiao, Dian, Xu, Xin, Su, Zheng, Wang, Yanming, Fan, Shiyong, Zhou, Xinbo, Li, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8676668/
https://www.ncbi.nlm.nih.gov/pubmed/34894942
http://dx.doi.org/10.1080/10717544.2021.2008053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8676668/
https://www.ncbi.nlm.nih.gov/pubmed/34894942
http://dx.doi.org/10.1080/10717544.2021.2008053

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