Aprepitant Promotes Caspase-Dependent Apoptotic Cell Death and G2/M Arrest through PI3K/Akt/NF-κB Axis in Cancer Stem-Like Esophageal Squamous Cell Carcinoma Spheres

The antagonists of the neurokinin-1 receptor (NK1R) are known for their anti-inflammatory, anxiolytic, antiemetic, and anticancer activities. Aprepitant, a nonpeptide NK1R antagonist, is used in nausea and vomiting, the most common side effects of cancer chemotherapy in patients. It has been establi...

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Detalles Bibliográficos
Autores principales: Javid, Hossein, Afshari, Amir R., Zahedi Avval, Farnaz, Asadi, Jahanbakhsh, Hashemy, Seyed Isaac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677400/
https://www.ncbi.nlm.nih.gov/pubmed/34926694
http://dx.doi.org/10.1155/2021/8808214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677400/
https://www.ncbi.nlm.nih.gov/pubmed/34926694
http://dx.doi.org/10.1155/2021/8808214

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