Induction of Th1 and Th2 in the protection against SARS-CoV-2 through mucosal delivery of an adenovirus vaccine expressing an engineered spike protein

A series of recombinant human type 5 adenoviruses that express the full-length or membrane-truncated spike protein (S) of SARS-CoV-2 (AdCoV2-S or AdCoV2-SdTM, respectively) was tested the efficacy against SARS-CoV-2 via intranasal (i.n.) or subcutaneous (s.c.) immunization in a rodent model. Mucosal...

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Detalles Bibliográficos
Autores principales: Chung, Nai-Hsiang, Chen, Ying-Chin, Yang, Shiu-Ju, Lin, Yu-Ching, Dou, Horng-Yunn, Hui-Ching Wang, Lily, Liao, Ching-Len, Chow, Yen-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677488/
https://www.ncbi.nlm.nih.gov/pubmed/34952759
http://dx.doi.org/10.1016/j.vaccine.2021.12.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677488/
https://www.ncbi.nlm.nih.gov/pubmed/34952759
http://dx.doi.org/10.1016/j.vaccine.2021.12.024

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