Cargando…

Induction of Th1 and Th2 in the protection against SARS-CoV-2 through mucosal delivery of an adenovirus vaccine expressing an engineered spike protein

A series of recombinant human type 5 adenoviruses that express the full-length or membrane-truncated spike protein (S) of SARS-CoV-2 (AdCoV2-S or AdCoV2-SdTM, respectively) was tested the efficacy against SARS-CoV-2 via intranasal (i.n.) or subcutaneous (s.c.) immunization in a rodent model. Mucosal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chung, Nai-Hsiang, Chen, Ying-Chin, Yang, Shiu-Ju, Lin, Yu-Ching, Dou, Horng-Yunn, Hui-Ching Wang, Lily, Liao, Ching-Len, Chow, Yen-Hung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677488/ https://www.ncbi.nlm.nih.gov/pubmed/34952759 http://dx.doi.org/10.1016/j.vaccine.2021.12.024

Ejemplares similares

SARS‐CoV‐2 spike protein enhances MAP4K3/GLK‐induced ACE2 stability in COVID‐19
por: Chuang, Huai‐Chia, et al.
Publicado: (2022)

Human SCARB2 Acts as a Cellular Associator for Helping Coxsackieviruses A10 Infection
por: Yu, Shu-Ling, et al.
Publicado: (2023)

A DNA vaccine candidate delivered by an electroacupuncture machine provides protective immunity against SARS-CoV-2 infection
por: Tzeng, Tsai-Teng, et al.
Publicado: (2022)

DNA vaccination induced protective immunity against SARS CoV-2 infection in hamsterss
por: Chai, Kit Man, et al.
Publicado: (2021)

Low-Dose SARS-CoV-2 S-Trimer with an Emulsion Adjuvant Induced Th1-Biased Protective Immunity
por: Liao, Hung-Chun, et al.
Publicado: (2022)

Correction: DNA vaccination induced protective immunity against SARS CoV-2 infection in hamsterss
por: Chai, Kit Man, et al.
Publicado: (2023)

Graptopetalum paraguayense Ameliorates Airway Inflammation and Allergy in Ovalbumin- (OVA-) Sensitized BALB/C Mice by Inhibiting Th2 Signal
por: Lee, Bao-Hong, et al.
Publicado: (2013)

Combining molecular typing and spatial pattern analysis to identify areas of high tuberculosis transmission in a moderate-incidence county in Taiwan
por: Chen, Yih-Yuan, et al.
Publicado: (2017)

Alarming dendritic cells for Th2 induction
por: MacDonald, Andrew S., et al.
Publicado: (2008)

Intranasal influenza vaccination using a new synthetic mucosal adjuvant SF‐10: induction of potent local and systemic immunity with balanced Th1 and Th2 responses
por: Kimoto, Takashi, et al.
Publicado: (2013)

Induction of Bcl-2 Expression by Hepatitis B Virus Pre-S2 Mutant Large Surface Protein Resistance to 5-Fluorouracil Treatment in Huh-7 Cells
por: Hung, Jui-Hsiang, et al.
Publicado: (2011)

11th International Conference on Multimedia and Ubiquitous Engineering & 12th International Conference on Future Information Technology
por: Park, James, et al.
Publicado: (2017)

Th17 Cytokines and the Gut Mucosal Barrier
por: Blaschitz, Christoph, et al.
Publicado: (2010)

Th22 cells and the intestinal mucosal barrier
por: Chen, Jieli, et al.
Publicado: (2023)

Induction of SerpinB2 and Th1/Th2 Modulation by SerpinB2 during Lentiviral Infections In Vivo
por: Major, Lee D., et al.
Publicado: (2013)

Draft Genome Sequence of Mycobacterium tuberculosis Clinical Strain W06, a Prevalent Beijing Genotype Isolated in Taiwan
por: Liao, Yu-Chieh, et al.
Publicado: (2015)

Furin and TMPRSS2 Resistant Spike Induces Robust Humoral and Cellular Immunity Against SARS-CoV-2 Lethal Infection
por: Lin, Jhe-Jhih, et al.
Publicado: (2022)

Th2 and Th17-Associated Immunopathology Following SARS-CoV-2 Breakthrough Infection in Spike-Vaccinated ACE2-humanized Mice
por: Zhang, Tianyi, et al.
Publicado: (2023)

Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants
por: Wu, Wan-Ling, et al.
Publicado: (2022)

Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice
por: Lee, Chen-Chen, et al.
Publicado: (2015)

Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness
por: Tsuyuki, Shogo, et al.
Publicado: (1997)

Adenoviruses as vectors for delivering vaccines to mucosal surfaces
por: Babiuk, L.A, et al.
Publicado: (2000)

GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2
por: Lin, Ritian, et al.
Publicado: (2022)

Corrigendum to “Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice”
por: Lee, Chen-Chen, et al.
Publicado: (2017)

T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination
por: Hemmi, Masahisa, et al.
Publicado: (2017)

Anticancer Effects of Helminthostachys zeylanica Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-α-activated COX-2-cPLA2-PGE(2) Pathway
por: Tsai, Ming-Ming, et al.
Publicado: (2021)

Basophils are required for the induction of Th2 immunity to haptens and peptide antigens
por: Otsuka, Atsushi, et al.
Publicado: (2013)

XBP1 is required in Th2 polarization induction in airway allergy
por: Zeng, Xianhai, et al.
Publicado: (2022)

Co-Expression of Coxsackievirus/Adenovirus Receptors and Desmoglein 2 in Lung Adenocarcinoma: A Comprehensive Analysis of Bioinformatics and Tissue Microarrays
por: Weng, Ching-Fu, et al.
Publicado: (2020)

Relationship between mucosal TNF-α expression and Th1, Th17, Th22 and Treg responses in Helicobacter pylori infection
por: Rahimian, Ghorbanali, et al.
Publicado: (2022)

Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni
Publicado: (1991)

Induction of Antibodies Protecting against Transmissible Gastroenteritis Coronavirus (TGEV) by Recombinant Adenovirus Expressing TGEV Spike Protein
por: TORRES, JUAN M., et al.
Publicado: (1995)

The Pattern of Cytokine Production In Vitro Induced by Ancient and Modern Beijing Mycobacterium tuberculosis Strains
por: Chen, Yih-Yuan, et al.
Publicado: (2014)

Poria cocos Modulates Th1/Th2 Response and Attenuates Airway Inflammation in an Ovalbumin-Sensitized Mouse Allergic Asthma Model
por: Chao, Chien-Liang, et al.
Publicado: (2021)

Pre-Existing Adenovirus Immunity Modifies a Complex Mixed Th1 and Th2 Cytokine Response to an Ad5/HIV-1 Vaccine Candidate in Humans
por: Pine, Samuel O., et al.
Publicado: (2011)

Community Outbreak of Adenovirus, Taiwan, 2011
por: Tsou, Tsung-Pei, et al.
Publicado: (2012)

Mutations in VP1 and 5′-UTR affect enterovirus 71 virulence
por: Chang, Ching-Kun, et al.
Publicado: (2018)

Author Correction: Mutations in VP1 and 5′-UTR affect enterovirus 71 virulence
por: Chang, Ching-Kun, et al.
Publicado: (2018)

Quality vaccines for all people(): Report on the 16th annual general meeting of the Developing Countries Vaccine Manufacturers' Network, 05–07th October 2015, Bangkok, Thailand
por: Pagliusi, Sonia, et al.
Publicado: (2016)

A Sliced Inverse Regression (SIR) Decoding the Forelimb Movement from Neuronal Spikes in the Rat Motor Cortex
por: Yang, Shih-Hung, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qh5e3bm9loh761m0v1ahf190v3