O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis

Aberrant glucose metabolism and elevated O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) are hallmarks of hepatocellular carcinoma (HCC). Loss of phosphoenolpyruvate carboxykinase 1 (PCK1), the major rate-limiting enzyme of hepatic gluconeogenesis, increases hexosamine biosynthetic pat...

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Detalles Bibliográficos
Autores principales: Liu, Rui, Gou, Dongmei, Xiang, Jin, Pan, Xuanming, Gao, Qingzhu, Zhou, Peng, Liu, Yi, Hu, Jie, Wang, Kai, Tang, Ni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677624/
https://www.ncbi.nlm.nih.gov/pubmed/34650217
http://dx.doi.org/10.1038/s41388-021-02058-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677624/
https://www.ncbi.nlm.nih.gov/pubmed/34650217
http://dx.doi.org/10.1038/s41388-021-02058-z

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