Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation

Therapies halting the progression of fibrosis are ineffective and limited. Activated myofibroblasts are emerging as important targets in the progression of fibrotic diseases. Previously, we performed a high-throughput screen on lung fibroblasts and subsequently demonstrated that the inhibition of my...

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Detalles Bibliográficos
Autores principales: Ring, Nadja Anneliese Ruth, Volpe, Maria Concetta, Stepišnik, Tomaž, Mamolo, Maria Grazia, Panov, Panče, Kocev, Dragi, Vodret, Simone, Fortuna, Sara, Calabretti, Antonella, Rehman, Michael, Colliva, Andrea, Marchesan, Pietro, Camparini, Luca, Marcuzzo, Thomas, Bussani, Rossana, Scarabellotto, Sara, Confalonieri, Marco, Pham, Tho X., Ligresti, Giovanni, Caporarello, Nunzia, Loffredo, Francesco S., Zampieri, Daniele, Džeroski, Sašo, Zacchigna, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677786/
https://www.ncbi.nlm.nih.gov/pubmed/34916483
http://dx.doi.org/10.1038/s41419-021-04439-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677786/
https://www.ncbi.nlm.nih.gov/pubmed/34916483
http://dx.doi.org/10.1038/s41419-021-04439-4

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