Connexin hemichannel inhibition ameliorates epidermal pathology in a mouse model of keratitis ichthyosis deafness syndrome

Mutations in five different genes encoding connexin channels cause eleven clinically defined human skin diseases. Keratitis ichthyosis deafness (KID) syndrome is caused by point mutations in the GJB2 gene encoding Connexin 26 (Cx26) which result in aberrant activation of connexin hemichannels. KID s...

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Detalles Bibliográficos
Autores principales: Sellitto, Caterina, Li, Leping, White, Thomas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677806/
https://www.ncbi.nlm.nih.gov/pubmed/34916582
http://dx.doi.org/10.1038/s41598-021-03627-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677806/
https://www.ncbi.nlm.nih.gov/pubmed/34916582
http://dx.doi.org/10.1038/s41598-021-03627-8

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