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Untangling the KRAS mutated lung cancer subsets and its therapeutic implications
The Kirsten rat sarcoma virus transforming protein (KRAS) mutations (predominate in codons 12, 13, and 61) and genomically drive nearly one-third of lung carcinomas. These mutations have complex functions in tumorigenesis, and influence the tumor response to chemotherapy and tyrosine kinase inhibito...
Autores principales: | Ritu, Kulshrestha, Kumar, Pawan, Singh, Amit, Nupur, K., Spalgias, Sonam, Mrigpuri, Parul, Rajkumar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677854/ https://www.ncbi.nlm.nih.gov/pubmed/34918209 http://dx.doi.org/10.1186/s43556-021-00061-0 |
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