Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives

Human ecto-5-nucleotidase (CD73) is involved in purinergic signalling, which influences a diverse range of biological processes. CD73 hydrolyses AMP and is the major control point for the levels of extracellular adenosine. Inhibitors of CD73 thus block the immunosuppressive action of adenosine, a pr...

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Detalles Bibliográficos
Autores principales: Scaletti, Emma, Huschmann, Franziska U., Mueller, Uwe, Weiss, Manfred S., Sträter, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677862/
https://www.ncbi.nlm.nih.gov/pubmed/34403084
http://dx.doi.org/10.1007/s11302-021-09802-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677862/
https://www.ncbi.nlm.nih.gov/pubmed/34403084
http://dx.doi.org/10.1007/s11302-021-09802-w

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