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Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives
Human ecto-5-nucleotidase (CD73) is involved in purinergic signalling, which influences a diverse range of biological processes. CD73 hydrolyses AMP and is the major control point for the levels of extracellular adenosine. Inhibitors of CD73 thus block the immunosuppressive action of adenosine, a pr...
Autores principales: | Scaletti, Emma, Huschmann, Franziska U., Mueller, Uwe, Weiss, Manfred S., Sträter, Norbert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677862/ https://www.ncbi.nlm.nih.gov/pubmed/34403084 http://dx.doi.org/10.1007/s11302-021-09802-w |
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