Computational Identification of Stearic Acid as a Potential PDK1 Inhibitor and In Vitro Validation of Stearic Acid as Colon Cancer Therapeutic in Combination with 5-Fluorouracil

BACKGROUND: Colorectal cancer is the third largest cause of cancer-related mortality worldwide. Although current treatments with chemotherapeutics have allowed for management of colorectal cancer, additional novel treatments are essential. Intervening with the metabolic reprogramming observed in can...

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Detalles Bibliográficos
Autores principales: Mitchel, Jonathan, Bajaj, Pratima, Patil, Ketki, Gunnarson, Austin, Pourchet, Emilie, Kim, Yoo Na, Skolnick, Jeffrey, Pai, S. Balakrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679029/
https://www.ncbi.nlm.nih.gov/pubmed/34924752
http://dx.doi.org/10.1177/11769351211065979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679029/
https://www.ncbi.nlm.nih.gov/pubmed/34924752
http://dx.doi.org/10.1177/11769351211065979

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