Cargando…

Computational Identification of Stearic Acid as a Potential PDK1 Inhibitor and In Vitro Validation of Stearic Acid as Colon Cancer Therapeutic in Combination with 5-Fluorouracil

BACKGROUND: Colorectal cancer is the third largest cause of cancer-related mortality worldwide. Although current treatments with chemotherapeutics have allowed for management of colorectal cancer, additional novel treatments are essential. Intervening with the metabolic reprogramming observed in can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mitchel, Jonathan, Bajaj, Pratima, Patil, Ketki, Gunnarson, Austin, Pourchet, Emilie, Kim, Yoo Na, Skolnick, Jeffrey, Pai, S. Balakrishna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679029/ https://www.ncbi.nlm.nih.gov/pubmed/34924752 http://dx.doi.org/10.1177/11769351211065979

Ejemplares similares

Stearic acid and carcinogenesis.
por: Habib, N. A., et al.
Publicado: (1987)

Molecular Dynamics: Investigating the Self-Association of Stearic Acid and Heteroassociation of Stearic Acid–Water in Cyclohexane
por: Sharifi, Najib
Publicado: (2023)

Dietary stearic acid regulates mitochondria in vivo in humans
por: Senyilmaz-Tiebe, Deniz, et al.
Publicado: (2018)

Ruminal microbe of biohydrogenation of trans-vaccenic acid to stearic acid in vitro
por: Li, Dan, et al.
Publicado: (2012)

Stearic acid content of abdominal adipose tissues in obese women
por: Caron-Jobin, M, et al.
Publicado: (2012)

Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid
por: Goradel, Nasser Hashemi, et al.
Publicado: (2016)

Correction: Preparation of glycerol monostearate from glycerol carbonate and stearic acid
por: Han, Li, et al.
Publicado: (2018)

Preparation and properties of capric acid–stearic acid-based ternary phase change materials
por: Du, Wenqing, et al.
Publicado: (2021)

Solid lipid nanoparticles modified with stearic acid–octaarginine for oral administration of insulin
por: Zhang, Zhen-Hai, et al.
Publicado: (2012)

Enzymatic Synthesis and Characterization of Hydrophilic Sugar Based Polyesters and Their Modification with Stearic Acid
por: Bilal, Muhammad Humayun, et al.
Publicado: (2016)

Calcium Sulfate with Stearic Acid as an Encouraging Carrier for Reindeer Bone Protein Extract
por: Tölli, Hanna, et al.
Publicado: (2011)

Selection of Cryoprotectant in Lyophilization of Progesterone-Loaded Stearic Acid Solid Lipid Nanoparticles
por: Amis, Timothy M., et al.
Publicado: (2020)

Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets
por: Zhang, Liu, et al.
Publicado: (2020)

Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins
por: Nůsková, Hana, et al.
Publicado: (2021)

Receptor-mediated gene delivery by folic acid-modified stearic acid-grafted chitosan micelles
por: Du, Yong-Zhong, et al.
Publicado: (2011)

Long-Chain Saturated Fatty Acids, Palmitic and Stearic Acids, Enhance the Repair of Photosystem II
por: Jimbo, Haruhiko, et al.
Publicado: (2020)

Interactions of Veratrum Alkaloids, Procaine, and Calcium with Monolayers of Stearic Acid and Their Implications for Pharmacological Action
por: Shanes, Abraham M., et al.
Publicado: (1960)

Brain-targeting study of stearic acid–grafted chitosan micelle drug-delivery system
por: Xie, Yi-Ting, et al.
Publicado: (2012)

Stearic Acid/Inorganic Porous Matrix Phase Change Composite for Hot Water Systems
por: Xu, Ling, et al.
Publicado: (2019)

Preparation and Evaluation of Novel Emodin-loaded Stearic Acid-g-chitosan Oligosaccharide Nanomicelles
por: Jiang, Xiaohong, et al.
Publicado: (2020)

Nanoscale Wear and Mechanical Properties of Calcite: Effects of Stearic Acid Modification and Water Vapor
por: Wojas, Natalia A., et al.
Publicado: (2021)

Hydrophobicity and Macroscale Tribology Behavior of Stearic Acid/Hydroxypropyl Methylcellulose Dual-Layer Composite
por: Shi, Shih-Chen, et al.
Publicado: (2021)

Synthesis of a new hydrophobic coating film from stearic acid of buffalo fat
por: Soliman, Hanaa M., et al.
Publicado: (2022)

Synthesis and Antiproliferative Insights of Lipophilic Ru(II)-Hydroxy Stearic Acid Hybrid Species
por: Drius, Giacomo, et al.
Publicado: (2023)

Stearic Acid as an Atomic Layer Deposition Inhibitor: Spectroscopic Insights from AFM-IR
por: Satyarthy, Saumya, et al.
Publicado: (2023)

Electrosprayed Stearic-Acid-Coated Ethylcellulose Microparticles for an Improved Sustained Release of Anticancer Drug
por: Ji, Yuexin, et al.
Publicado: (2023)

Propaedeutic study for the delivery of nucleic acid-based molecules from PLGA microparticles and stearic acid nanoparticles
por: Grassi, G, et al.
Publicado: (2006)

Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men
por: Gebauer, S K, et al.
Publicado: (2014)

Preparation and characterization of lauric acid–stearic acid/expanded perlite as a composite phase change material
por: Liu, Xuying, et al.
Publicado: (2022)

Mutations in SACPD-C Result in a Range of Elevated Stearic Acid Concentration in Soybean Seed
por: Carrero-Colón, Militza, et al.
Publicado: (2014)

Dietary Stearic Acid Leads to a Reduction of Visceral Adipose Tissue in Athymic Nude Mice
por: Shen, Ming-Che, et al.
Publicado: (2014)

A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity
por: Liu, Zhuguo, et al.
Publicado: (2015)

Silymarin-Loaded Nanoparticles Based on Stearic Acid-Modified Bletilla striata Polysaccharide for Hepatic Targeting
por: Ma, Yanni, et al.
Publicado: (2016)

Vitamin C/Stearic Acid Hybrid Monolayer Adsorption at Air–Water and Air–Solid Interfaces
por: Ahmed, Ikbal, et al.
Publicado: (2018)

Stearic Acid/Layered Double Hydroxides Composite Thin Films Deposited by Combined Laser Techniques
por: Birjega, Ruxandra, et al.
Publicado: (2020)

Synergistic Influences of Stearic Acid Coating and Recycled PET Microfibers on the Enhanced Properties of Composite Materials
por: Nguyen, Dang Mao, et al.
Publicado: (2020)

Encapsulation of Variabilin in Stearic Acid Solid Lipid Nanoparticles Enhances Its Anticancer Activity in Vitro
por: Lerata, Mookho S., et al.
Publicado: (2020)

l-Carnitine conjugated chitosan-stearic acid polymeric micelles for improving the oral bioavailability of paclitaxel
por: Yang, Tan, et al.
Publicado: (2020)

Effect of Podophyllotoxin Conjugated Stearic Acid Grafted Chitosan Oligosaccharide Micelle on Human Glioma Cells
por: Wang, Geng Huan, et al.
Publicado: (2020)

Effects of ultrasonication on the properties of maize starch/stearic acid/ sodium carboxymethyl cellulose composite film
por: Liu, Pengfei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v6c4mqgie2td896foudvf0gg18