Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma

BACKGROUND: Glypican-3 (GPC-3) is an oncofetal protein that is highly expressed in various solid tumors, but rarely expressed in healthy adult tissues and represents a rational target of particular relevance in hepatocellular carcinoma (HCC). Autologous chimeric antigen receptor (CAR) αβ T cell ther...

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Detalles Bibliográficos
Autores principales: Makkouk, Amani, Yang, Xue (Cher), Barca, Taylor, Lucas, Anthony, Turkoz, Mustafa, Wong, Jonathan T S, Nishimoto, Kevin P, Brodey, Mary M, Tabrizizad, Maryam, Gundurao, Smitha R Y, Bai, Lu, Bhat, Arun, An, Zili, Abbot, Stewart, Satpayev, Daulet, Aftab, Blake T, Herrman, Marissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679077/
https://www.ncbi.nlm.nih.gov/pubmed/34916256
http://dx.doi.org/10.1136/jitc-2021-003441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679077/
https://www.ncbi.nlm.nih.gov/pubmed/34916256
http://dx.doi.org/10.1136/jitc-2021-003441

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