Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire

The Tcra repertoire is generated by multiple rounds of V(α)-J(α) rearrangement. However, Tcrd recombination precedes Tcra recombination within the complex Tcra-Tcrd locus. Here, by ablating Tcrd recombination, we report that Tcrd rearrangement broadens primary V(α) use to diversify the Tcra repertoi...

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Detalles Bibliográficos
Autores principales: Dauphars, Danielle J., Mihai, Ariana, Wang, Liuyang, Zhuang, Yuan, Krangel, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679779/
https://www.ncbi.nlm.nih.gov/pubmed/34910107
http://dx.doi.org/10.1084/jem.20211581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679779/
https://www.ncbi.nlm.nih.gov/pubmed/34910107
http://dx.doi.org/10.1084/jem.20211581

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