B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

The germinal center (GC) is a site where somatic hypermutation and clonal selection are coupled for antibody affinity maturation against infections. However, how GCs are formed and regulated is incompletely understood. Here, we identified an unexpected role of Tank-binding kinase-1 (TBK1) as a cruci...

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Detalles Bibliográficos
Autores principales: Lee, Michelle S.J., Inoue, Takeshi, Ise, Wataru, Matsuo-Dapaah, Julia, Wing, James B., Temizoz, Burcu, Kobiyama, Kouji, Hayashi, Tomoya, Patil, Ashwini, Sakaguchi, Shimon, Simon, A. Katharina, Bezbradica, Jelena S., Nagatoishi, Satoru, Tsumoto, Kouhei, Inoue, Jun-Ichiro, Akira, Shizuo, Kurosaki, Tomohiro, Ishii, Ken J., Coban, Cevayir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679780/
https://www.ncbi.nlm.nih.gov/pubmed/34910106
http://dx.doi.org/10.1084/jem.20211336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679780/
https://www.ncbi.nlm.nih.gov/pubmed/34910106
http://dx.doi.org/10.1084/jem.20211336

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