The Kynurenine Pathway Metabolites QA and KYNA induce senescence in Bone Marrow Stem Cells through the AhR Pathway

Cell senescence is emerging as a critical factor in the pathophysiology of aging bone loss. We have shown that the essential amino acid tryptophan is metabolized by IDO-1 in the periphery to generate kynurenine (KYN), and that KYN can signal though the aryl hydrocarbon receptor (AhR) transcription f...

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Detalles Bibliográficos
Autores principales: Kondrikov, Dmitry, Elmansi, Ahmed, Shi, Xing-ming, McGee-Lawrence, Meghan, Fulzele, Sadanand, Hamrick, Mark, Isales, Carlos, Hill, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680082/
http://dx.doi.org/10.1093/geroni/igab046.171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680082/
http://dx.doi.org/10.1093/geroni/igab046.171

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