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Long-term oral administration of a novel estrogen receptor beta agonist enhances memory and alleviates drug-induced vasodilation in young ovariectomized mice

Development of estrogen therapies targeting the β (ERβ) but not α (ERα) estrogen receptor is critically needed for the treatment of negative menopausal symptoms, as ERα activation increases health risks like cancer. Here, we determined the effects of long-term oral treatment with EGX358, a novel hig...

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Detalles Bibliográficos
Autores principales: Fleischer, Aaron W., Schalk, Jayson C., Wetzel, Edward A., Hanson, Alicia M., Sem, Daniel S., Donaldson, William A., Frick, Karyn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680219/
https://www.ncbi.nlm.nih.gov/pubmed/33571507
http://dx.doi.org/10.1016/j.yhbeh.2021.104948