Co-targeting MCL-1 and ERK1/2 kinase induces mitochondrial apoptosis in rhabdomyosarcoma cells

The RAS/MEK/ERK genetic axis is commonly altered in rhabdomyosarcoma (RMS), indicating high activity of downstream effector ERK1/2 kinase. Previously, we have demonstrated that inhibition of the RAS/MEK/ERK signaling pathway in RMS is insufficient to induce cell death due to residual pro-survival MC...

Descripción completa

Detalles Bibliográficos
Autores principales: Winkler, Marius, Friedrich, Juliane, Boedicker, Cathinka, Dolgikh, Nadezda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681038/
https://www.ncbi.nlm.nih.gov/pubmed/34906889
http://dx.doi.org/10.1016/j.tranon.2021.101313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681038/
https://www.ncbi.nlm.nih.gov/pubmed/34906889
http://dx.doi.org/10.1016/j.tranon.2021.101313

Ejemplares similares