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Co-targeting MCL-1 and ERK1/2 kinase induces mitochondrial apoptosis in rhabdomyosarcoma cells

The RAS/MEK/ERK genetic axis is commonly altered in rhabdomyosarcoma (RMS), indicating high activity of downstream effector ERK1/2 kinase. Previously, we have demonstrated that inhibition of the RAS/MEK/ERK signaling pathway in RMS is insufficient to induce cell death due to residual pro-survival MC...

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Detalles Bibliográficos
Autores principales:	Winkler, Marius, Friedrich, Juliane, Boedicker, Cathinka, Dolgikh, Nadezda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681038/ https://www.ncbi.nlm.nih.gov/pubmed/34906889 http://dx.doi.org/10.1016/j.tranon.2021.101313

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