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Targeting kynurenine metabolism to reduce inflammation and enhance stress response during aging

Aberrant kynurenine pathway metabolism is increasingly linked to aging and age-associated disease. Kynurenine metabolic activity increases with age and becomes dysregulated during various forms of age-associated pathology in humans. By manipulating one or more kynurenine pathway enzymes and metaboli...

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Detalles Bibliográficos
Autores principales: Sutphin, George, Dang, Hope, Espejo, Luis, Castro-Portuguez, Raul, Hull, Bradford, Meyers, Jeremy, Turner, Emily, DeNicola, Destiny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681472/
http://dx.doi.org/10.1093/geroni/igab046.2565