FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism

Mutations in genes encoding mitochondrial aminoacyl-tRNA synthetases are linked to diverse diseases. However, the precise mechanisms by which these mutations affect mitochondrial function and disease development are not fully understood. Here, we develop a Drosophila model to study the function of d...

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Detalles Bibliográficos
Autores principales: Fan, Wenlu, Jin, Xiaoye, Xu, Man, Xi, Yongmei, Lu, Weiguo, Yang, Xiaohang, Guan, Min-Xin, Ge, Wanzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682739/
https://www.ncbi.nlm.nih.gov/pubmed/34878141
http://dx.doi.org/10.1093/nar/gkab1187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682739/
https://www.ncbi.nlm.nih.gov/pubmed/34878141
http://dx.doi.org/10.1093/nar/gkab1187

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