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FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism

Mutations in genes encoding mitochondrial aminoacyl-tRNA synthetases are linked to diverse diseases. However, the precise mechanisms by which these mutations affect mitochondrial function and disease development are not fully understood. Here, we develop a Drosophila model to study the function of d...

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Detalles Bibliográficos
Autores principales:	Fan, Wenlu, Jin, Xiaoye, Xu, Man, Xi, Yongmei, Lu, Weiguo, Yang, Xiaohang, Guan, Min-Xin, Ge, Wanzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682739/ https://www.ncbi.nlm.nih.gov/pubmed/34878141 http://dx.doi.org/10.1093/nar/gkab1187

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