A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrations

Here, we report that in T47D breast cancer cells 50 pM progestin is sufficient to activate cell cycle entry and the progesterone gene expression program. At this concentration, equivalent to the progesterone blood levels found around the menopause, progesterone receptor (PR) binds only to 2800 genom...

Descripción completa

Detalles Bibliográficos
Autores principales: Zaurin, Roser, Ferrari, Roberto, Nacht, Ana Silvina, Carbonell, Jose, Le Dily, Francois, Font-Mateu, Jofre, de Llobet Cucalon, Lara Isabel, Vidal, Enrique, Lioutas, Antonios, Beato, Miguel, Vicent, Guillermo P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682742/
https://www.ncbi.nlm.nih.gov/pubmed/34850111
http://dx.doi.org/10.1093/nar/gkab1125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682742/
https://www.ncbi.nlm.nih.gov/pubmed/34850111
http://dx.doi.org/10.1093/nar/gkab1125

Ejemplares similares