Cargando…

A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrations

Here, we report that in T47D breast cancer cells 50 pM progestin is sufficient to activate cell cycle entry and the progesterone gene expression program. At this concentration, equivalent to the progesterone blood levels found around the menopause, progesterone receptor (PR) binds only to 2800 genom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zaurin, Roser, Ferrari, Roberto, Nacht, Ana Silvina, Carbonell, Jose, Le Dily, Francois, Font-Mateu, Jofre, de Llobet Cucalon, Lara Isabel, Vidal, Enrique, Lioutas, Antonios, Beato, Miguel, Vicent, Guillermo P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682742/ https://www.ncbi.nlm.nih.gov/pubmed/34850111 http://dx.doi.org/10.1093/nar/gkab1125

Ejemplares similares

Progesterone receptor induces bcl-x expression through intragenic binding sites favoring RNA polymerase II elongation
por: Bertucci, Paola Y., et al.
Publicado: (2013)

The embryonic linker histone dBigH1 alters the functional state of active chromatin
por: Climent-Cantó, Paula, et al.
Publicado: (2020)

Erk signaling and chromatin remodeling in MMTV promoter activation by progestins
por: Vicent, Guillermo P., et al.
Publicado: (2009)

Two Chromatin Remodeling Activities Cooperate during Activation of Hormone Responsive Promoters
por: Vicent, Guillermo Pablo, et al.
Publicado: (2009)

The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells
por: Ogara, Maria F, et al.
Publicado: (2019)

Coordinated changes in gene expression, H1 variant distribution and genome 3D conformation in response to H1 depletion
por: Serna-Pujol, Núria, et al.
Publicado: (2022)

Hypothesis-driven probabilistic modelling enables a principled perspective of genomic compartments
por: Kariti, Hagai, et al.
Publicado: (2023)

Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses
por: Bolt, Michael J., et al.
Publicado: (2013)

Validation of human microRNA target pathways enables evaluation of target prediction tools
por: Kern, Fabian, et al.
Publicado: (2020)

STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells
por: Richart, Laia, et al.
Publicado: (2021)

Explicit DNase sequence bias modeling enables high-resolution transcription factor footprint detection
por: Yardımcı, Galip Gürkan, et al.
Publicado: (2014)

Designer epigenome modifiers enable robust and sustained gene silencing in clinically relevant human cells
por: Mlambo, Tafadzwa, et al.
Publicado: (2018)

A viral suppressor of RNA silencing inhibits ARGONAUTE 1 function by precluding target RNA binding to pre-assembled RISC
por: Kenesi, Erzsébet, et al.
Publicado: (2017)

Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light
por: Chen, Xianjun, et al.
Publicado: (2016)

An intronic structure enabled by a long-distance interaction serves as a novel target for splicing correction in spinal muscular atrophy
por: Singh, Natalia N., et al.
Publicado: (2013)

Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing
por: Pérez-Lluch, Sílvia, et al.
Publicado: (2011)

The Polycomb protein RING1B enables estrogen-mediated gene expression by promoting enhancer–promoter interaction and R-loop formation
por: Zhang, Yusheng, et al.
Publicado: (2021)

PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
por: Mayayo-Peralta, Isabel, et al.
Publicado: (2023)

Chromatin-dependent regulation of RNA polymerases II and III activity throughout the transcription cycle
por: Jordán-Pla, Antonio, et al.
Publicado: (2015)

Binding site profiles and N-terminal minor groove interactions of the master quorum-sensing regulator LuxR enable flexible control of gene activation and repression
por: Zhang, Jun, et al.
Publicado: (2021)

Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets
por: Nelson, Christopher S., et al.
Publicado: (2013)

Long-range chromatin interactions at the mouse Igf2/H19 locus reveal a novel paternally expressed long non-coding RNA
por: Court, Franck, et al.
Publicado: (2011)

The distribution of active RNA polymerase II along the transcribed region is gene-specific and controlled by elongation factors
por: Rodríguez-Gil, Alfonso, et al.
Publicado: (2010)

Uncoupling histone turnover from transcription-associated histone H3 modifications
por: Ferrari, Paolo, et al.
Publicado: (2015)

The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons
por: García-Martínez, José, et al.
Publicado: (2016)

A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae
por: Rodríguez-Galán, Olga, et al.
Publicado: (2020)

The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation
por: Gómez-Herreros, Fernando, et al.
Publicado: (2017)

NF-κB directly mediates epigenetic deregulation of common microRNAs in Epstein-Barr virus-mediated transformation of B-cells and in lymphomas
por: Vento-Tormo, Roser, et al.
Publicado: (2014)

Abf1 and other general regulatory factors control ribosome biogenesis gene expression in budding yeast
por: Bosio, Maria Cristina, et al.
Publicado: (2017)

The transcriptional co-activator PCAF regulates cdk2 activity
por: Mateo, Francesca, et al.
Publicado: (2009)

Intestinal differentiation involves cleavage of histone H3 N-terminal tails by multiple proteases
por: Ferrari, Karin Johanna, et al.
Publicado: (2021)

The interplay between DNA methylation and sequence divergence in recent human evolution
por: Hernando-Herraez, Irene, et al.
Publicado: (2015)

A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells
por: Cantu', Claudio, et al.
Publicado: (2011)

Body temperature variation controls pre-mRNA processing and transcription of antiviral genes and SARS-CoV-2 replication
por: Los, Bruna, et al.
Publicado: (2022)

CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing
por: Kerschbamer, Emanuela, et al.
Publicado: (2022)

The transcription factor Sox5 modulates Sox10 function during melanocyte development
por: Stolt, C. Claus, et al.
Publicado: (2008)

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex
por: Thiaville, Michelle M., et al.
Publicado: (2008)

S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum
por: André, Gaëlle, et al.
Publicado: (2008)

The CaMV transactivator/viroplasmin interferes with RDR6-dependent trans-acting and secondary siRNA pathways in Arabidopsis
por: Shivaprasad, Padubidri V., et al.
Publicado: (2008)

Expanded binding specificity of the human histone chaperone NASP
por: Wang, Huanyu, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_mtk8ivn4bg2r567peu80e1l5ro