Perinuclear positioning of endosomes can affect PS-ASO activities

Phosphorothioate (PS) modified antisense oligonucleotide (ASO) drugs that act on cellular RNAs must enter cells and be released from endocytic organelles to elicit antisense activity. It has been shown that PS-ASOs are mainly released by late endosomes. However, it is unclear how endosome movement i...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Xue-hai, Nichols, Joshua G, Tejera, Dario, Crooke, Stanley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682747/
https://www.ncbi.nlm.nih.gov/pubmed/34878127
http://dx.doi.org/10.1093/nar/gkab1198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682747/
https://www.ncbi.nlm.nih.gov/pubmed/34878127
http://dx.doi.org/10.1093/nar/gkab1198

Ejemplares similares