Functional role and ribosomal position of the unique N-terminal region of DHX29, a factor required for initiation on structured mammalian mRNAs

Translation initiation on structured mammalian mRNAs requires DHX29, a DExH protein that comprises a unique 534-aa-long N-terminal region (NTR) and a common catalytic DExH core. DHX29 binds to 40S subunits and possesses 40S-stimulated NTPase activity essential for its function. In the cryo-EM struct...

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Detalles Bibliográficos
Autores principales: Sweeney, Trevor R, Dhote, Vidya, Guca, Ewelina, Hellen, Christopher U T, Hashem, Yaser, Pestova, Tatyana V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682770/
https://www.ncbi.nlm.nih.gov/pubmed/34883515
http://dx.doi.org/10.1093/nar/gkab1192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682770/
https://www.ncbi.nlm.nih.gov/pubmed/34883515
http://dx.doi.org/10.1093/nar/gkab1192

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