Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells

Understanding chemoresistance mechanisms in BRCA-deficient cells will allow for identification of biomarkers for predicting tumor response to therapy, as well as the design of novel therapeutic approaches targeting this chemoresistance. Here, we show that the protein MED12, a component of the Mediat...

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Detalles Bibliográficos
Autores principales: Jackson, Lindsey M, Dhoonmoon, Ashna, Hale, Anastasia, Dennis, Kady A, Schleicher, Emily M, Nicolae, Claudia M, Moldovan, George-Lucian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682781/
https://www.ncbi.nlm.nih.gov/pubmed/34871431
http://dx.doi.org/10.1093/nar/gkab1184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682781/
https://www.ncbi.nlm.nih.gov/pubmed/34871431
http://dx.doi.org/10.1093/nar/gkab1184

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