Somatic intronic TP53 c.375+5G mutations are a recurrent but under‐recognized mode of TP53 inactivation

TP53 is one of the most ubiquitously altered genes in human cancer. The biological impact of rare variants, particularly those located within noncoding regions, remains poorly understood. From interrogation of clinical massively parallel sequencing data from over 55,000 tumors, which included 23,330...

Descripción completa

Detalles Bibliográficos
Autores principales: Chui, M Herman, Yang, Ciyu, Mehta, Nikita, Rai, Vikas, Zehir, Ahmet, Momeni Boroujeni, Amir, Ladanyi, Marc, Mandelker, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682938/
https://www.ncbi.nlm.nih.gov/pubmed/34505757
http://dx.doi.org/10.1002/cjp2.242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682938/
https://www.ncbi.nlm.nih.gov/pubmed/34505757
http://dx.doi.org/10.1002/cjp2.242

Ejemplares similares