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Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders

Precise and noninvasive theranostic methods to quantify and deplete focal iron are of crucial importance for iron-overload disorders. Here, we developed an indocyanine green (ICG)–based imaging platform to reveal Fe(3+) in vitro and in vivo. The high sensitivity and specificity of ICG-Fe interaction...

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Autores principales: Lin, Huirong, Zhou, Yu, Wang, Jiaming, Wang, Huimeng, Yao, Tianhong, Chen, Hu, Zheng, Huili, Zhang, Yang, Ren, En, Jiang, Lai, Chu, Chengchao, Chen, Xiaoyuan, Mao, Jingsong, Wang, Fudi, Liu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682994/
https://www.ncbi.nlm.nih.gov/pubmed/34919434
http://dx.doi.org/10.1126/sciadv.abl5862
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author Lin, Huirong
Zhou, Yu
Wang, Jiaming
Wang, Huimeng
Yao, Tianhong
Chen, Hu
Zheng, Huili
Zhang, Yang
Ren, En
Jiang, Lai
Chu, Chengchao
Chen, Xiaoyuan
Mao, Jingsong
Wang, Fudi
Liu, Gang
author_facet Lin, Huirong
Zhou, Yu
Wang, Jiaming
Wang, Huimeng
Yao, Tianhong
Chen, Hu
Zheng, Huili
Zhang, Yang
Ren, En
Jiang, Lai
Chu, Chengchao
Chen, Xiaoyuan
Mao, Jingsong
Wang, Fudi
Liu, Gang
author_sort Lin, Huirong
collection PubMed
description Precise and noninvasive theranostic methods to quantify and deplete focal iron are of crucial importance for iron-overload disorders. Here, we developed an indocyanine green (ICG)–based imaging platform to reveal Fe(3+) in vitro and in vivo. The high sensitivity and specificity of ICG-Fe interaction facilitated MR images with a marked correlation between T(1) signal intensity ratio (T(1)SIR) changes and Fe(3+) concentration in rodent models and humans. On the basis of these findings, a rational design for coordination-driven self-assembly ICG-Lecithin (ICG/Leci) was proposed to determine Fe(3+). The enhancement of photoacoustic signal at 890 nm with increasing Fe(3+) concentration showed an over 600% higher linear slope than that of T(1)SIR changes in animal models. ICG/Leci also promoted a 100% increase in iron depletion in the liver compared with deferoxamine. The high MR sensitivity and superior photoacoustic contrast, combined with enhanced iron depletion, demonstrate that ICG/Leci is a promising theranostic agent for simultaneous detection and treatment of iron-overload disorders.
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spelling pubmed-86829942021-12-29 Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders Lin, Huirong Zhou, Yu Wang, Jiaming Wang, Huimeng Yao, Tianhong Chen, Hu Zheng, Huili Zhang, Yang Ren, En Jiang, Lai Chu, Chengchao Chen, Xiaoyuan Mao, Jingsong Wang, Fudi Liu, Gang Sci Adv Physical and Materials Sciences Precise and noninvasive theranostic methods to quantify and deplete focal iron are of crucial importance for iron-overload disorders. Here, we developed an indocyanine green (ICG)–based imaging platform to reveal Fe(3+) in vitro and in vivo. The high sensitivity and specificity of ICG-Fe interaction facilitated MR images with a marked correlation between T(1) signal intensity ratio (T(1)SIR) changes and Fe(3+) concentration in rodent models and humans. On the basis of these findings, a rational design for coordination-driven self-assembly ICG-Lecithin (ICG/Leci) was proposed to determine Fe(3+). The enhancement of photoacoustic signal at 890 nm with increasing Fe(3+) concentration showed an over 600% higher linear slope than that of T(1)SIR changes in animal models. ICG/Leci also promoted a 100% increase in iron depletion in the liver compared with deferoxamine. The high MR sensitivity and superior photoacoustic contrast, combined with enhanced iron depletion, demonstrate that ICG/Leci is a promising theranostic agent for simultaneous detection and treatment of iron-overload disorders. American Association for the Advancement of Science 2021-12-17 /pmc/articles/PMC8682994/ /pubmed/34919434 http://dx.doi.org/10.1126/sciadv.abl5862 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Physical and Materials Sciences
Lin, Huirong
Zhou, Yu
Wang, Jiaming
Wang, Huimeng
Yao, Tianhong
Chen, Hu
Zheng, Huili
Zhang, Yang
Ren, En
Jiang, Lai
Chu, Chengchao
Chen, Xiaoyuan
Mao, Jingsong
Wang, Fudi
Liu, Gang
Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders
title Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders
title_full Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders
title_fullStr Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders
title_full_unstemmed Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders
title_short Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders
title_sort repurposing icg enables mr/pa imaging signal amplification and iron depletion for iron-overload disorders
topic Physical and Materials Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682994/
https://www.ncbi.nlm.nih.gov/pubmed/34919434
http://dx.doi.org/10.1126/sciadv.abl5862
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